Background: Chemotherapy has become one of the methods that are being adopted to treat
cancer. Coumarins, thiazoles and thiadiazoles are versatile synthetic scaffolds possessing wide spectrum
of biological effects including potential anticancer activity.
Objective: In the efforts to develop suitable anticancer drugs, medicinal chemists have focused on
coumarin derivatives. A series of novel thiazole-pyranochromene and thiadiazole-pyranochromene derivatives
were synthesized via heterocyclization of varies hydrazonoyl halides with methyl pyrano[3,2-
g]chromen-3-yl)ethylidene)hydrazine-1-carbodithioate and pyrano[3,2-g]chromen-3-yl)ethylidene)-
Method: All the newly synthesized compounds have been characterized on the basis of elemental
analysis and spectral data (IR, 1H and 13C NMR, Mass). Moreover, all the products were evaluated for
their anticancer activity against HEPG2-1.
Results: The results revealed that six new compounds showed promising anticancer activity.
Conclusion: In the present paper, 3-acetyl-5-methoxy-8-methyl-2H,6H-pyrano[3,2-g]chromene-2,6-
dione proved to be a useful precursor for synthesis of various 1,3-thiazoles and 1,2,4-thiadiazoles incorporating
pyrano[3,2-g]chromene moiety as anticancer agents. The computational studies using
MOE 2014.09 software are confirming the results in biological activity.