Background: Diverse chronic disease arises with aging including cardiac and neurodegenerative
disorders. Oxidative stress is considered to be the important cause of aging which
can affect various vital organs and lead to a general reduction in physiological functions. The
brain is the most sensitive organ towards such oxidative stress due to high oxygen consumption
and higher metabolism. Aging of the brain can impair the cognitive skills and memory which
lead to the demented condition. The histopathological hallmarks of dementia are a neuronal loss
in the forebrain, generation of amyloid β plaque and neurofibrillary tangles. It eventually abolishes
the thinking skill and memory.
Objective: Thus, dementia is a major public health concern, with economic and social burden, of
which occurrence is greatly increasing. There is no cure for dementia, however, only a few approved
drugs are available for the management of the demented condition. Hence, there is a need
of alternative medicine for effective treatment and management.
Method: Nowadays, several herbal products have been introduced with their neuroprotective effects,
with additional advantages of being low cost, easily available and with fewer side effects.
Conclusion: This review represented the pathophysiology of dementia, classification with current
therapy and advancement in plant products for their potential neuroprotective properties.