Chimeric Antigen Receptor T Cell Based Immunotherapy for Cancer

Author(s): Feng Li, Tengfei Zhang, Ling Cao, Yi Zhang*.

Journal Name: Current Stem Cell Research & Therapy

Volume 13 , Issue 5 , 2018

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Abstract:

Cancer immunotherapy, a new weapon against cancers by harnessing the patient's own immune system, potentiates an extended remission and possibly a cure for cancer. T cells genetically engineered with chimeric antigen receptor (CAR) vectors can specifically target the surface antigen of cancer cells and kill them in an MHC-independent manner. CD19 is extensively expressed on cancerous cells in B cell malignancies. To target this antigen, CAR T cells have gained great success in treating patients with B cell leukemia and lymphoma. Currently, the data from clinical trials on CAR T cells in solid tumors are limited; thus, CAR T cells targeting GD2, HER2, EGFRvIII, CSPG4, DNAX, mesothelin, and other molecules are under active investigation for solid tumors. In this review, we summarize the clinical results for CAR T cells in the case of hematologic and solid tumors, along with the current developments in CAR T cell immunotherapy.

Keywords: Cancer immunotherapy, CAR T cells, hematologic malignancies, solid tumor, cancer cells, leukemia.

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Article Details

VOLUME: 13
ISSUE: 5
Year: 2018
Page: [327 - 335]
Pages: 9
DOI: 10.2174/1574888X13666180420110239
Price: $58

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