Genoprotective Effect of New Triazine Derivatives in Endosulfan Mediated Toxicity, an In vivo and In vitro Study

Author(s): Nima Naderi, Seyed Mostafa Ghasemi Najarkolaee, Mona Modanlookordi, Mohammad Shokrzadeh, Hamid Irannejad*.

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 1 , 2019

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Abstract:

Background: Recently, we reported synthesis and neuroprotective activity of some new 1,2,4-triazine derivatives against H2O2 and β-amyloid toxicity in two neurotic cell lines, SHSY5Y and PC12.

Methods: The promising results obtained prompted us to further study on these potent neuroprotective agents. In the current study, in vivo anti-inflammatory effect and also genoprotective activity of these compounds in endosulfan-mediated toxicity were investigated. Compounds RT and SMO exhibited high anti-inflammatory effect at 3 and 4 hours after injection in 20 mg/kg, and were even more effective than Indomethacin (20 mg/kg).

Results: Interestingly, compound SMO in 200 µM was the best compound in reducing micronuclei significantly (P value <0.0001) in lymphocytes treated with endosulfan compared to control group.

Conclusion: Herein, we report SMO as a genoprotective agent and a new drug candidate for endosulfan mediated toxicity.

Keywords: Genoprotection, 1, 2, 4-triazine, anti-inflammatory, endosulfan, neuroprotective, neurotic cell lines.

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Article Details

VOLUME: 16
ISSUE: 1
Year: 2019
Page: [52 - 57]
Pages: 6
DOI: 10.2174/1570180815666180420095446
Price: $58

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