Effect of Zinc Supplementation on Lipid Profile in Obese People: A Systematic Review

Author(s): Juliana S. Severo, Jennifer B.S. Morais, Jessica B. Beserra, Luciana M. de Farias, Loanne R. dos Santos, Stéfany R. de Sousa Melo, Nadir do Nascimento Nogueira, Dilina do Nascimento Marreiro*.

Journal Name: Current Nutrition & Food Science

Volume 15 , Issue 6 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Background: Many studies have investigated the influence of minerals on the control of changes in lipid metabolism in obese individuals. The objective of this study was to describe, in a systematic review, the clinical trial outcomes of zinc supplementation and lipid profiles of obese participants.

Methods: This review was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations. A survey was conducted for selecting clinical trials related to the effects of zinc supplementation on lipid profiles in obese people, using the following databases: PubMed, SciVerse ScienceDirect and Cochrane.

Results: After the selection process, five articles were identified as eligible for this review and it was observed that the clinical trials included adults and children of both sexes, in three different countries, and with zinc supplementation doses ranging from 20 to 100 mg/day. None of the studies observed changes in High-Density Lipoprotein (HDL-c) with zinc supplementation. On the other hand, three studies observed a positive effect of zinc supplementation on triglycerides, and two found an effect on Low-Density Lipoprotein (LDL-c) and total cholesterol.

Conclusion: The results of this systematic review provide evidence on the benefits of zinc supplementation on lipid profiles in obese individuals. However, new intervention studies are needed to elucidate the function of the nutrient in protection against disorders related to lipid metabolism, as well as the standardization of the type, dose, and time of zinc supplementation.

Keywords: Lipid metabolism, lipoproteins, obesity, supplementation, triglycerides, zinc.

Bays H, Jones PH, Jacobson TA, et al. Lipids and bariatric procedures part 1 of 2: Scientific statement from the National Lipid Association (NLA), American Society for Matabolic and Bariatric Surgery (ASMBS), and Obesity Medicine Association (OMA). J Clin Lipidol 2016; 10(1): 15-32.
Koliaki C, Roden M. Alterations of mitochondrial function and insulin sensitivity in human obesity and diabetes mellitus. Annu Rev Nutr 2016; 36: 337-67.
Parish RC, Todman S, Jain SK. Resting heart rate variability, inflammation, and insulin resistance in overweight and obese adolescents. Metab Syndr Relat Disord 2016; 14(6): 291-7.
Chang CJ, Jian DY, Lin MW, Zhao J-Z, Ho LT, Juan CC. Evidence in obese children: contribution of hyperlipidemia, obesity-inflammation, and insulin sensitivity. PloS One 2015; 10(5)e0125935
Gaidhu MP, Anthony NM, Patel P, Hawke TJ, Ceddia RB. Dysregulation of lipolysis and lipid metabolism in visceral and subcutaneous adipocytes by high-fat diet: role of ATGL, HSL, and AMPK. Am J Physiol Cell Physiol 2010; 298(4): 961-71.
Oliveira ARS, Cruz KJC, Severo JS, et al. Hypomagnesemia and its relation with chronic low-grade inflammation in obesity. Rev Assoc Med Bras 2017; 63(2): 164-71.
Nikolic D, Katsiki N, Montalto G, Isenovic ER, Mikhailidis DP, Rizzo M. Lipoprotein subfractions in metabolic syndrome and obesity: clinical significance and therapeutic approaches. Nutrients 2013; 5(3): 928-48.
Cruz KJC, Morais JBS, Oliveira ARS, Severo JS, Marreiro DN. The effect of zinc supplementation on insulin resistance in obese subjects: a systematic review. Biol Trace Elem Res 2017; 176(2): 239-43.
Foster M, Herulah UN, Prasad A, Petocz P, Samman S. Zinc status of vegetarians during pregnancy: a systematic review of observational studies and meta-analysis of zinc intake. Nutrients 2015; 7(6): 4512-25.
Fung EB, Gildengorin G, Talwar S, Hagar L, Lal A. Zinc status affects glucose homeostasis and insulin secretion in patients with thalassemia. Nutrients 2015; 7(6): 4296-307.
Ferro FED, Lima VBS, Soares NRM, Cozzolino SMF, Marreiro DN. Parameters of metabolic syndrome and its relationship with zincemia and activities of superoxide dismutase and glutathione peroxidase in obese women. Biol Trace Elem Res 2011; 143: 787-93.
Martins LM, Oliveira ARS, Cruz KJC, et al. Influence of cortisol on zinc metabolism in morbidly obese women. Nutr Hosp 2014; 29: 57-63.
Begin-Heick N, Dalpe-Scott M, Rowe J, Heick HMC. Zinc supplementation attenuates insulin secretory activity in pancreatic islets of the ob/ob mouse. Diabetes 1985; 34(2): 179-84.
Foster M, Samman S. Zinc and regulation of inflammatory cytokines: implications for cardiometabolic disease. Nutrients 2012; 4(7): 676-94.
Hashemipour M, Kelishadi R, Shapouri J, et al. Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children. Hormones 2009; 8(4): 279-85.
Kelishadi R, Hashemipour M, Adeli K, et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord 2010; 8(6): 505-10.
Payahoo L, Ostadrahimi A, Mobasseri M, et al. Effects of zinc supplementation on the anthropometric measurements, lipid profiles and fasting blood glucose in the healthy obese adults. Adv Pharm Bull 2013; 3(1): 161-5.
Gómez-García A, Hernández-Salazar E, González-Ortiz M, Martínez-Abundis E. Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad. Rev Med Chile 2006; 134(3): 279-84.
Kim J, Lee S. Effect of zinc supplementation on insulin resistance and metabolic risk factors in obese Korean women. Nutr Res Pract 2012; 6(3): 221-5.
Morais JBS, Severo JS, Alencar GRR, et al. Effect of magnesium supplementation on insulin resistance in humans: a systematic review. Nutrition 2017; 38: 54-60.
Ranasinghe P, Wathurapatha WS, Ishara MH, et al. Effects of zinc supplementation on serum lipids: a systematic review and meta analysis. Nutr Metab 2015; 12: 26.
Li X, Guan Y, Shi X, et al. Effects of high zinc levels on the lipid synthesis in rat hepatocytes. Biol Trace Elem Res 2013; 154(1): 97-102.
Ahmadian M, Suh JM, Hah N, et al. PPARγ signaling and metabolism: the good, the bad and the future. Nat Med 2013; 19(5): 557-66.
Shen H, MacDonald R, Bruemmer D, et al. Zinc deficiency alters lipid metabolism in ldl receptor–deficient mice treated with rosiglitazone. J Nutr 2007; 137(11): 2339-45.
Hughes S, Samman S. The effect of zinc supplementation in humans on plasma lipids, antioxidant status and thrombogenesis. J Am Coll Nutr 2006; 25(4): 285-91.
Hooper PL, Visconti L, Garry PJ, Johnson GE. Zinc lowers high density lipoprotein-cholesterol levels. JAMA 1980; 244(17): 1960-1.
Fosmire GJ. Zinc toxicity. Am J Clin Nutr 1990; 51(2): 225-7.
Foster M, Petocz P, Samman S. Effects of zinc on plasma lipoprotein cholesterol concentrations in humans: a meta-analysis of randomised controlled trials. Atherosclerosis 2010; 210(2): 344-52.
Xu C, Liu L, Luo C, Lu G, Li Q, Gao X. Zinc regulates lipid metabolism and MMPs expression in lipid disturbance rabbits. Biol Trace Elem Res 2015; 168(2): 411-20.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2019
Page: [551 - 556]
Pages: 6
DOI: 10.2174/1573401314666180420094522
Price: $65

Article Metrics

PDF: 36
PRC: 1