Introduction: Buxus sempervirens L. is used in Morocco as a plant with some medicinal
properties including treatment of diabetes and cardiovascular diseases.
Methods: The objective of the study was to assess the effect of the aqueous extract of Buxus
sempervirens L. (Boxwood) leaves on the blood lipid parameters including total cholesterol,
triglycerides, High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol
(LDL-C) and Very Low-Density Lipoprotein Cholesterol (VLDL-C) in normal and streptozotocininduced
diabetic rats. In addition, antioxidant activity of aqueous Buxus sempervirens extract was
evaluated by DPPH and FRAP assays.
Results: The results indicated a significant decrease in serum total cholesterol and LDL-C levels,
while, no change was observed on triglycerides and VLDL-C values in diabetic rats. Lipid profile
of normal animals did not reveal any modification. In addition the aqueous extract of Buxus
sempervirens exerted a significant antioxidant activity. Therefore, the results suggest that the
aqueous extract of Buxus sempervirens exhibits lipid lowering activity which could be due partially
to its antioxidant ability.
Conclusion: In conclusion, Buxus sempervirens leaf extract may be helpful in controlling the
development of hyperlipidemia as well as atherosclerosis in diabetic animals.