Buxus sempervirens L. Improves Lipid Profile in Diabetic Rats

Author(s): Mohammed Ajebli, Mohamed Eddouks*.

Journal Name: Cardiovascular & Hematological Disorders-Drug Targets

Volume 18 , Issue 3 , 2018

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Abstract:

Introduction: Buxus sempervirens L. is used in Morocco as a plant with some medicinal properties including treatment of diabetes and cardiovascular diseases.

Methods: The objective of the study was to assess the effect of the aqueous extract of Buxus sempervirens L. (Boxwood) leaves on the blood lipid parameters including total cholesterol, triglycerides, High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C) and Very Low-Density Lipoprotein Cholesterol (VLDL-C) in normal and streptozotocininduced diabetic rats. In addition, antioxidant activity of aqueous Buxus sempervirens extract was evaluated by DPPH and FRAP assays.

Results: The results indicated a significant decrease in serum total cholesterol and LDL-C levels, while, no change was observed on triglycerides and VLDL-C values in diabetic rats. Lipid profile of normal animals did not reveal any modification. In addition the aqueous extract of Buxus sempervirens exerted a significant antioxidant activity. Therefore, the results suggest that the aqueous extract of Buxus sempervirens exhibits lipid lowering activity which could be due partially to its antioxidant ability.

Conclusion: In conclusion, Buxus sempervirens leaf extract may be helpful in controlling the development of hyperlipidemia as well as atherosclerosis in diabetic animals.

Keywords: Buxus sempervirens L., diabetic, lipid profile, antioxidant, hyperlipidemia, atherosclerosis.

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Article Details

VOLUME: 18
ISSUE: 3
Year: 2018
Page: [239 - 246]
Pages: 8
DOI: 10.2174/1871529X18666180419100823
Price: $58

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