Sperm thermotaxis, namely the temperature-oriented motility of sperm cells, is a key
process involved in ejaculated sperm guidance towards the oocyte for fertilization pourposes. Since
its discovery in 2003, many studies clarified the dynamics, the sensitivity and the overall weight of
this process in the comprehensive context of fertilization. However, the identification of sperm thermosensor/
s remained elusive until recently. The most recent cues about the molecular bases of the old
known process of thermotaxis are here revised. Moreover, the possible pathophysiological and therapeutic
repercussions deriving from the widening of this process are also discussed.
Keywords: Sperm, thermotaxis, fertilization, sperm-egg interaction, temperature-sensing receptor, opsin system.
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