Title:Rhamnazin: A Systematic Review on Ethnopharmacology, Pharmacology and Analytical Aspects of an Important Phytomedicine
VOLUME: 4 ISSUE: 2
Author(s):Kanika Patel, Vikas Kumar, Mahfoozur Rahman, Amita Verma and Dinesh Kumar Patel*
Affiliation:Department of Pharmaceutical Science, Shalom Institute of Health and Allied Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad 211007, Uttar Pradesh, Department of Pharmaceutical Science, Shalom Institute of Health and Allied Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad 211007, Uttar Pradesh, Department of Pharmaceutical Science, Shalom Institute of Health and Allied Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad 211007, Uttar Pradesh, Department of Pharmaceutical Science, Shalom Institute of Health and Allied Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad 211007, Uttar Pradesh, Department of Pharmaceutical Science, Shalom Institute of Health and Allied Sciences, Faculty of Health Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Allahabad 211007, Uttar Pradesh
Keywords:Analytical aspects, antioxidant, flavonoid, Pharmacological activities, phytochemicals, polyphenols.
Abstract:Flavonoids are the important class of phytochemicals, which are mainly present
in the various parts of plant such as fruits, leaves, flowers and specially berries. In earlier
days, flavonoids have been known for their antioxidant properties only. Among all flavonoids,
quercetin and rutin are the most usable flavonoids reported. Day to day, their demand
is increasing in the realm of pharmaceuticals, biotechnological and nutraceutical industries
due to their significant features in healthcare applications. Some important plants such as
apples, tea plant, onions, red grapes, citrus fruits, curly kale, leeks, broccoli, cherries, raspberry,
cranberry, blueberry, tomatoes, soya and blackberries contain flavonoid in maximum
quantification limits and are so called the best sources for them. Flavonoids containing two
basic nuclei such as flavan and flavones, which are further categorized into flavones, flavonols,
flavanones, flavan-3-ols, isoflavones and anthocyanidins. Rhamnazin’ or 5,4’-
dihydroxy-7,5’-dimethoxyflavonol is commonly found in Artemisia, Alnus, Betula, Aesculus
and Rhamnus spp. Rhamnazin gained wider acceptance among bio-actives for healthcare
benefits due to its antioxidant, antibacterial, antiangiogenic and anti-tumor properties.
Furthermore, anti-infective and anti-proliferative properties are not much explored yet,
which have attracted the attention of the researchers. Therefore, the present review
extensively discussed the scientific aspects of ‘rhamnazin’ and its derivatives with respect to
its medicinal uses, pharmacological activities, separation, isolation and various analytical
techniques.
