The initial uses of ultrasound waves in the medical field were limited to the
thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the
preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug
delivery when the agent is administered encapsulated inside a nanoparticle. This spatial
and temporal control of drug release, using a non-invasive modality, is a promising
approach to decrease the side effects of conventional chemotherapy in cancer
treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several
examples on the use of nanoparticles as drug carriers, with a focus on liposomes.
Examples of in vitro and in vivo studies are presented and discussed.
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
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