Abstract
The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
Current Molecular Medicine
Title:Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
Volume: 17 Issue: 10
Author(s): N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor and G.A. Husseini*
Affiliation:
- Department of Chemical Engineering, American University of Sharjah, Sharjah,United Arab Emirates
Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.
Abstract: The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.
In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.
Export Options
About this article
Cite this article as:
Salkho N.M., Turki R.Z., Guessoum O., Martins A.M., Vitor R.F. and Husseini G.A.*, Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment, Current Molecular Medicine 2017; 17 (10) . https://dx.doi.org/10.2174/1566524018666180416100142
DOI https://dx.doi.org/10.2174/1566524018666180416100142 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Bioaccessibility of Bioactive Compounds and Prebiotic Properties of Fruit and Vegetable By-products - A Mini Review
Current Bioactive Compounds Gefitinib Represses JAK-STAT Signaling Activated by CRTC1-MAML2 Fusion in Mucoepidermoid Carcinoma Cells
Current Cancer Drug Targets Editorial [Hot topic: A Dawn of New Era of Signal Transduction in Radiation Oncology (Guest Editor: Yuzuru Niibe)]
Current Signal Transduction Therapy Meet Our Editorial Board Member
Anti-Cancer Agents in Medicinal Chemistry Correlation between Potassium Channel Expression and Sensitivity to Drug-induced Cell Death in Tumor Cell Lines
Current Pharmaceutical Design Promising Gene Therapy Using an Adenovirus Vector Carrying REIC/Dkk-3 Gene for the Treatment of Biliary Cancer
Current Gene Therapy Autoimmune Hepatitis
Current Pediatric Reviews Autophagy as a Molecular Target of Flavonoids Underlying their Protective Effects in Human Disease
Current Medicinal Chemistry Advances on Semisynthesis, Total Synthesis, and Structure-Activity Relationships of Honokiol and Magnolol Derivatives
Mini-Reviews in Medicinal Chemistry Circadian Rhythm in Cytokines Administration
Mini-Reviews in Medicinal Chemistry Liver Radioembolization: An Analysis of Parameters that Influence the Catheter-Based Particle-Delivery via CFD
Current Medicinal Chemistry Malignant Pleural Effusions: Review of Treatment and Our Experience
Reviews on Recent Clinical Trials Pharmacological Modulation of Nitric Oxide Release: New Pharmacological Perspectives, Potential Benefits and Risks
Current Medicinal Chemistry Response to Rituximab: Has the Original Hypothesis Been Confirmed?
Current Pharmaceutical Design Precursors of Magnetic Resonance Imaging Contrast Agents Based on Cystine-coated Iron-oxide Nanoparticles
Current Physical Chemistry Editorial [Hot Topic: Mammalian Target of Rapamycin as a Therapeutic Target in Leukemia (Executive Editors: Francis J. Giles / Maher Albitar)]
Current Molecular Medicine Cancer Multitarget Pharmacology in Prostate Tumors: Tyrosine Kinase Inhibitors and Beyond
Current Medicinal Chemistry Stem Cell-Mediated Gene Delivering for the Treatment of Cerebral Ischemia: Progress and Prospectives
Current Drug Targets Combining Anti-tumor Alkyl-Phospholipid Analogs and Radiotherapy: Rationale and Clinical Outlook
Anti-Cancer Agents in Medicinal Chemistry Tumor Invasion and Oxidative Stress: Biomarkers and Therapeutic Strategies
Current Molecular Medicine