Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment

Author(s): N.M. Salkho, R.Z. Turki, O. Guessoum, A.M. Martins, R.F. Vitor, G.A. Husseini*.

Journal Name: Current Molecular Medicine

Volume 17 , Issue 10 , 2017

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Abstract:

The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a powerful tool to improve drug delivery when the agent is administered encapsulated inside a nanoparticle. This spatial and temporal control of drug release, using a non-invasive modality, is a promising approach to decrease the side effects of conventional chemotherapy in cancer treatments, as it reduces the interaction of the anti-neoplastic agent with healthy tissues.

In this review, we explain the physics of ultrasound, introduce and discuss several examples on the use of nanoparticles as drug carriers, with a focus on liposomes. Examples of in vitro and in vivo studies are presented and discussed.

Keywords: Cancer, liposomes, drug delivery, ultrasound, drug release, anti-neoplastic agent.

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Article Details

VOLUME: 17
ISSUE: 10
Year: 2017
Page: [668 - 688]
Pages: 21
DOI: 10.2174/1566524018666180416100142
Price: $58

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