Sublingual route increases the efficacy of the drug by dissolving in few seconds
in the oral cavity. Being a fast dissolving tablet the sublingual tablet is mostly acceptable
in an emergency because it does not require chewing as well as water for administration.
An important advantage of the sublingual route is that it bypasses the hepatic
circulation of the drug ultimately increasing the bioavailability of the drug with
rapid onset of action and patient compliance. It is a very suitable route of administration
especially for pediatric, geriatric and psychiatric patients having difficulty in swallowing
(dysphagia). Sublingual route is more permeable as compared to buccal and gingival
route due to the rapid onset of action of the drug when administered by sublingual route.
In the developing countries vaccination for the prohibition of various diseases is routinely
done so sublingual route is the most preferable because of the large surface area
and immunological competence. Mucosal tissues are attractive administration and target
sites for vaccination. This review focused on the different sublingual dosage forms, advantages,
and factors affecting sublingual absorption, methods of preparation and various
in vitro and in vivo evaluation parameters of the sublingual tablet.
Keywords: Sublingual delivery, bioavailability, sublingual tablet, first pass, oral drug administration,
drug delivery system.
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