Introduction: Chronic serum uric acid elevation (SUA) is known to be induced by
dyslipidemia, hypertension, inflammation, and insulin resistance. Therefore, it has been associated
with higher risk for coronary artery disease and cardiovascular mortality. Also, increased levels of
SUA have been associated with regional arterial stiffness, assessed by pulse wave velocity (PWV).
Aims: To evaluate the relationships of PWV, SUA and different metabolic parameters in essential
Material and Methods: We evaluated 445 essential hypertensive patients, by measuring office
blood pressure (BP), weight, height, and waist circumference. In each patient, blood samples were
drawn for biochemical evaluations and 24h urine collection. Body Mass Index (BMI) and Glomerular
Filtration Rate (GFR) were calculated. Carotid-Femoral PWV and Left Ventricular Mass Index
(LVMI) were measured in all patients.
Results: All subjects (n=402), 242 males (55±0.9 yrs.; BMI: 28.9±0.3 Kg/m2) and 160 females
(58±1 yrs.; BMI: 28.1±0.4 Kg/m2) had normal renal function. PWV values showed a significant
association with SUA (p<0.001), Systolic BP (p<0.025) and LVMI (p<0.05). SUA showed a significant
association, p<0.025: with BMI, Waist Circumference, and HDL-C; p<0.05: with Glycaemia
at 120 min, Insulin at 120 min, TG, and LVMI; and p<0.001: with serum Creatinine. Backward
Stepwise Regression showed that PWV could be predicted from SUA (p<0.001) and Systolic BP
(p<0.05). BMI, Waist Circumference, DBP and HR did not significantly add to the ability of the
equation to predict PWV.
Conclusions: In this population of essential hypertensive patients, SUA was associated to increased
arterial stiffness and to components of the Metabolic Syndrome. These results raise the possibility
that a new approach to the role of SUA, linked to cardiovascular stratification, and a most appropriate
treatment might be considered.