Background: Assisted Reproduction Techniques (ART) have significantly advanced
since the first successful In Vitro Fertilization (IVF). However, most in vitro–produced embryos
fail to implant. Key steps in ART are the correct infertility diagnosis, in order to manage the individualised
treatments, and the assessment of gamete and embryo viability, to identify the embryo
with the best implantation potential.
Objective: The goal for this manuscript was to present a brief review of proteomics in Assisted
Reproduction Technologies (ART) and raises the question of whether proteomics is a good alternative
for the future of ART.
Methods: A literature review concerning proteomics and assisted reproduction was conducted.
Results: Non-invasive approaches to correctly diagnose infertility and to access embryo development
potential have the advantages of increasing our knowledge about embryo physiology, therefore
allowing the development of methods to predict developmental competence and viability.
These approaches include proteomic profiling and other omics technologies.
Conclusion: The use of proteomics in clinical practice goes beyond the identification of the oocytes
and embryos with the best developmental potentials, it may add to the diagnosis of both male and
female infertility and in the future, it may be a laboratory tool that will contribute to the birth of a