K2PdCl4/PPh3-catalyzed Carbon-sulfur Coupling Reaction; An Efficient and One-pot Method to Direct Synthesis of Organic Disulfides/Sulfides from Aryl Halides and Thiourea

Title:K2PdCl4/PPh3-catalyzed Carbon-sulfur Coupling Reaction; An Efficient and One-pot Method to Direct Synthesis of Organic Disulfides/Sulfides from Aryl Halides and Thiourea

Volume: 15 Issue: 11

Author(s): Masoumeh Raeisi, Fariba Mohammadi, Mohammad Soleiman-Beigi*Ali Naghipour

Affiliation:

• Department of Chemistry, Basic of Sciences Faculty, Ilam University, Ilam,Iran

Keywords: Palladium catalyst, organic disulfides/sulfides, cross-coupling reaction, thiourea, K2PdCl4, halides.

Abstract: This work describes an efficient and new catalyst for the one-pot synthesis of organic disulfides/ sulfides via a palladium catalyst in the presence of PPh3 ligands for domino cross-coupling reaction of aryl halides and thiourea and then sulfur-transformation. Finally, the generated aryl thiolate converts to disulfide at normal oxidative and atmospheric conditions in DMF/water. However, thiols convert to unsymmetrical sulfides by one-pot reaction with alkyl halides in PEG/H2O.

Cite this article as:

Raeisi Masoumeh , Mohammadi Fariba , Soleiman-Beigi Mohammad *, Naghipour Ali , K2PdCl4/PPh3-catalyzed Carbon-sulfur Coupling Reaction; An Efficient and One-pot Method to Direct Synthesis of Organic Disulfides/Sulfides from Aryl Halides and Thiourea, Letters in Organic Chemistry 2018; 15 (11) . https://dx.doi.org/10.2174/1570178615666180412122502