K2PdCl4/PPh3-catalyzed Carbon-sulfur Coupling Reaction; An Efficient and One-pot Method to Direct Synthesis of Organic Disulfides/Sulfides from Aryl Halides and Thiourea

Author(s): Masoumeh Raeisi, Fariba Mohammadi, Mohammad Soleiman-Beigi*, Ali Naghipour.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 11 , 2018

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Abstract:

This work describes an efficient and new catalyst for the one-pot synthesis of organic disulfides/ sulfides via a palladium catalyst in the presence of PPh3 ligands for domino cross-coupling reaction of aryl halides and thiourea and then sulfur-transformation. Finally, the generated aryl thiolate converts to disulfide at normal oxidative and atmospheric conditions in DMF/water. However, thiols convert to unsymmetrical sulfides by one-pot reaction with alkyl halides in PEG/H2O.

Keywords: Palladium catalyst, organic disulfides/sulfides, cross-coupling reaction, thiourea, K2PdCl4, halides.

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Article Details

VOLUME: 15
ISSUE: 11
Year: 2018
Page: [899 - 904]
Pages: 6
DOI: 10.2174/1570178615666180412122502
Price: $58

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