Background: Epidemiological studies have shown the role of high dietary fat intake as a
risk factor for Neuropsychiatric Disorders (NPDs). However, the exact mechanism of this
phenomenon is unknown.
Methods: An electronic search was performed using Scopus, PubMed and Google Scholar regarding
the association of high fat intake and inflammatory reactions and their roles in the etiopathogenesis of
Results: The results indicate that high fat intake is involved in the development of severe
inflammatory reactions. Inflammation is also involved in the pathophysiology of NPDs. Therefore, it
is suggested that high fat intake might be involved in the development of NPDs through induction of
Conclusion: It is suggested that reducing fat intake might decline the risk of NPDs.