A new sesquiterpene, litopharbdiol along with five known metabolites of terpenes and sterols
were isolated and identified from the methanolic extract of the Red Sea soft coral Litophyton
arboreum. The structures of the isolated compounds were elucidated on the basis of their 1D- and 2DNMR
and MS spectral data. In parallel, the total extract was evaluated for its in vivo genotoxicity and
antigenotoxicity against the mutagenicity induced by the anticancer drug cyclophosphamide (CP). The
extract was found to be safe and nongenotoxic at 100 mg/kg b.wt. Moreover, the mice group of CP pretreated
with the extract (100 mg/kg b.wt) showed significant reduction in the percentage of chromosomal
aberrations induced in bone marrow and mouse spermatocytes.
Keywords: Sesquiterpene, NMR, soft coral, Litophyton arboretum, genotoxicity, antigenotoxicity.
Rights & PermissionsPrintExport