Background: Neuronal α4β2 nAChRs are receptors involved in the role of neurotransmitters
regulation and release, and this ionic channel participates in biological process of memory, learning and
attention. This work aims to review the structure and functioning of the α4β2 nAChR emphasizing its role
in the treatment of associated diseases like nicotine addiction and underlying pathologies such as cognition,
depression and attention-deficit hyperactivity disorder.
Methods: The authors realized extensive bibliographic research using the descriptors “Nicotine Receptor
α4β2” and “cognition”, “depression”, “attention-deficit hyperactivity disorder”, besides cross-references
of the selected articles and after analysis of references in the specific literature.
Results: As results, it was that found 179 relevant articles presenting the main molecules with affinity to
nAChR α4β2 related to the cited diseases. The α4β2 nAChR subtype is a remarkable therapeutic target
since this is the most abundant receptor in the central nervous system.
Conclusion: In summary, this review presents perspectives on the pharmacology and therapeutic targeting
of α4β2 nAChRs for the treatment of cognition and diseases like nicotine dependence, depression and
attention-deficit hyperactivity disorder.