Alzheimer disease (AD) is most common neurodegenerative disorder of dementia, as we all
know that ApoE4 is the greatest genetic risk factor of late-onset Alzheimer's disease (LOAD). Coronary
heart disease (CHD) leads to one-fourth of all deaths in industrialized countries, it is reported that
ApoE4 increases the risk of coronary heart disease as well. Furthermore, evidence show that coronary
heart disease also increases the incidence of Alzheimer's disease. Whether ApoE4 is a bridge connecting
AD with CHD or not? And what are the special mechanism and therapeutic methods? Researchers
found that cholesterol metabolic disorder is the common cause and risk factor of AD and CHD. Epidemiological
studies demonstrate that carriers of the ApoE4 allele have higher cholesterol plasma concentration.
More evidence indicate that hypercholesterolemia accelerates the progression of coronary
atherosclerosis, damages the central nervous system blood-brain barrier, promotes Aβ protein production
and Tau deposition in brain. Therefore, ApoE4 is likely to be the bridge between AD and CHD,
and may be a potentially promising therapeutic target.
Keywords: ApoE4, coronary heart disease (CHD), Alzheimer's disease (AD), central nervous system, hypercholesterolemia,
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