Continued emergence and spread of multidrug-resistant bacteria behooved the development
of alternative treatment strategies, including antimicrobial drugs. A hopeful approach is to target cellto-
cell communications, commonly known as quorum-sensing (QS) and microbial biofilm formation.
Quorum Sensing is a method used on bacteria to determine their physiological behavior and coordinate
gene expression based on the cell to cell signaling. Many physiological functions of bacteria are
controlled by quorum sensings such as virulence, motility, sporulation, luminescence, and biofilm
formation. Microbial biofilms are organized aggregations of cells attached to a substratum and surrounded
by a self-produced extrapolymeric substance (EPS) matrix. Currently, biofilm formation and
quorum sensing are considered as a prospective novel target for antimicrobial therapy to control multidrug-
resistant infections. Plant-based natural products have been comprehensively studied in this
context. In this review, a comprehensive overview of various research papers published in the last
decade on plant-derived molecules that are capable of inhibiting quorum sensing or microbial biofilm
formation is reviewed, mentioning the biosynthetic classes of active compounds and their biological
activity in the performed assays.
Keywords: Antibacterial activity, biofilm, medicinal plants, quorum sensing inhibitor, multidrug-resistant bacteria.
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