RNA interference (RNAi) or Post-Transcriptional Gene Silencing is a
strong mechanism of gene silencing which is moderated by MicroRNAs (miRNAs),
underlying many fields of eukaryotic biology. The miRNAs are small noncoding
RNAs and a gene regulation expression system which showing a tissue-specific expression
pattern, and inhibits protein synthesis. For the first time, miRNA has been
seen in Caenorhabditis elegans. They play an important role in signaling pathways
of various diseases especially periodontal disease during periodontal inflammation
and oral cancers. The most important miRNAs in periodontal diseases and oral
squamous cell carcinoma are miR-142-3p, miR-146a, miR-155, miR-203, and miR-
223. One of the most important diseases in association with gingival infectious is
periodontal diseases which if left untreated, would lead to tooth loss. Hence, the aim
of the present study is to focus the effects of miRNAs and their targets in diseases
which are mentioned above.
Keywords: MicroRNA, MicroRNA regulation expression, Biomarkers, Periodontal diseases, Porphyromonas
gingivalis, Photodynamic therapy.
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