Hematopoiesis is the process which generates all the mature blood cells
from the rare pool of Hematopoietic stem cells (HSCs). Asymmetric cell division of
HSCs provide it dual capacity for self-renewal and multi-potent differentiation.
Hematopoiesis is a steady state process in which mature blood cells are produced at
the same rate at which they are lost, establishing a homeostasis. HSCs are regulated
through their environmental niche, cytokine signalling, and the orchestrated activities
of various transcription factors. However, there is very little information available
about the signal transduction events that regulate HSC function; in particular, the effects
of bioactive lipids and lipid mediators are not well understood. Recent studies
have added an important aspect of this process, introducing the role of lipids in cell
fate decisions during hematopoiesis. The mechanisms of bioactive lipids and their
derivatives have been studied extensively in signal transduction and various other
This review focuses on various categories of lipids and their regulatory mechanisms
in HSCs and their comment into different blood cells. Moreover, we also discuss the
role of lipid signalling specifically in megakaryocyte and platelets.
Keywords: HSC, Megakaryocyte, Eicosanoids, Phosphatidylinositides, Ceramide, Hematopoiesis.
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