Pediatric Hematological Malignancies – Clinical Manifestation, Treatment and Follow-Up
Pp. 138-183 (46)
Naga Ramya Lanka and Krishna Kanth Pulicherla
Hematological malignancies are the forms of cancer that begin in the cells of
the blood- forming tissue, such as the bone marrow. Childhood blood cancers are
relatively rare but are still found to be the major cause of death in children aged 1-14.
Early detection increases the chances of successful treatment which paves the way to
reduce the rate of mortality. Leukemias and lymphomas account for more than one half
of new cancer cases in children. Despite major advances – from an overall survival rate
of 10 percent to nearly 90 percent today, for many rare cancers, the survival rate is
much lower. Enhancement of anti-leukemic efficacy and reduction of treatment related
morbidity or mortality can be achieved by targeted therapy, but requires detailed
understanding of pathways and genetic defects involved in leukemogenesis.
Acute lymphoblastic leukemia, Acute myeloid leukemia,
Adolescents, Cancer, Chemotherapy, Childhood, Children, Cytogenetics,
Dyspnea, EBV, Etiology, Follow-up, Genetic abnormalities, Hematological
malignancies, Hemolytic anemia, Hemolytic uremic syndrome, Hodgkin,
Immunophenotyping, Late effects, Leukemia, Leukocytosis, Lymphoma, Non
hodgkins, Paediatric cancer emergencies, Paediatric emergiencies, Physician’s
role, Sarcoma, Targeted therapy.
Department of Science and Technology, Ministry of Science and Technology, Govt. of India, Technology Bhavan, New Mehrauli Road, New Delhi-110016, India.