Background: A series of chalcones and flavones were synthesized from
2’-hydroxyacetophenone and substituted aromatic aldehydes via Simmons-Schmidt condensation
followed by oxidative cyclization.
Methods: Characterization of the obtained structures was established on the basis of their spectroscopic
data. The synthesized compounds were screened for their antimicrobial activities against five
bacterial strains (Citrobacter freundii, Staphylococcus aureus, Listeria monocytogenes, Salmonella
braenderup, Escherichia coli.) and two fungal strains (Candida albicans, Candida krusei).
Results: The in vitro bioassay results indicated that some target compounds displayed moderate
(4d, 4e) to high (4a) antifungal activity against the pathogenic fungi C. albicans and C. krusei.
Conclusion: For the antibacterial activity, only products 3d and 4d showed a weak antibacterial
activity. These compounds can lead to the design of new drugs with specific antifungal activity.