Synthesis of a Series of Chalcones and Related Flavones and Evaluation of their Antibacterial and Antifungal Activities

Author(s): Hind Benouda, Btissam Bouchal, Allal Challioui, Abdelkader Oulmidi, Tarik Harit, Fouad Malek, Abdelkhalek Riahi, Mohammed Bellaoui*, Boufelja Bouammali*.

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 1 , 2019

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Graphical Abstract:


Background: A series of chalcones and flavones were synthesized from 2’-hydroxyacetophenone and substituted aromatic aldehydes via Simmons-Schmidt condensation followed by oxidative cyclization.

Methods: Characterization of the obtained structures was established on the basis of their spectroscopic data. The synthesized compounds were screened for their antimicrobial activities against five bacterial strains (Citrobacter freundii, Staphylococcus aureus, Listeria monocytogenes, Salmonella braenderup, Escherichia coli.) and two fungal strains (Candida albicans, Candida krusei).

Results: The in vitro bioassay results indicated that some target compounds displayed moderate (4d, 4e) to high (4a) antifungal activity against the pathogenic fungi C. albicans and C. krusei.

Conclusion: For the antibacterial activity, only products 3d and 4d showed a weak antibacterial activity. These compounds can lead to the design of new drugs with specific antifungal activity.

Keywords: Antibacterial activity, antifungal activity, chalcones, flavones, simmons-schmidt condensation, fluconazole.

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Article Details

Year: 2019
Page: [93 - 100]
Pages: 8
DOI: 10.2174/1570180815666180404130430
Price: $58

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