Gene Silencing Strategies in Cancer Therapy: An Update for Drug Resistance

(E-pub Ahead of Print)

Author(s): Sanaz Naghizadeh, Behzad Mansoori, Ali Mohammadi, Ebrahim Sakhinia , Behzad Baradaran*.

Journal Name: Current Medicinal Chemistry

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RNAi, post-transcriptional gene silencing mechanism, could be considered as one of the most important breakthroughs and rapidly growing fields in science. Researchers are trying to use this discovery in the treatment of various diseases and cancer is one of them. Multiple treatment procedures for treatmentresistant cancers remain as an unsolvable problem yet. The current review summarizes both transcriptional and post-transcriptional gene silencing mechanisms, and highlights mechanisms leading to drug-resistance such as, drug efflux, drug inactivation, drug target alteration, DNA damages repair, and the epithelialmesenchymal transition, as well as the role of tumor cell heterogeneity and tumor microenvironment, involving genes in these processes. It ultimately points out the obstacles of RNAi application for in vivo treatment of diseases and progressions that have been achieved in this field.

Keywords: Drug resistance, Gene silencing, cancer, RNA interference.

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(E-pub Ahead of Print)
DOI: 10.2174/0929867325666180403141554
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