Pigments from Filamentous Ascomycetes for Combination Therapy

Author(s): Róbert Hromádka , Zdeněk Kejík , Milan Jakubek , Robert Kaplánek , Viera Šandriková , Marian Urban , Pavel Martásek , Vladimír Král* .

Journal Name: Current Medicinal Chemistry

Volume 26 , Issue 20 , 2019

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Abstract:

Filamentous ascomycetes (Neurospora and Monascus) have been studied for a long time because of their production of secondary metabolites such as microbial pigments. The ascomycetes represent an interesting group of compounds with high potential for medicinal applications. Many recent studies have shown their efficacy in the treatment of serious pathological states such as oncological diseases, neurodegenerative diseases and hyperlipidaemia. Nevertheless, the clinical usability of ascomycetes is still limited. However, this problem can be solved by the use of these compounds with combinations of other therapeutic agents. This strategy can suppress their side effects and improve their therapeutic efficacy. Moreover, their co-application can significantly enhance conventional therapies that are used. This review summarizes and discusses the general principles of this approach, introduced and supported by numerous examples. In addition, the prediction of the future potential application of this methodology is included.

Keywords: Filamentous ascomycetes, Neurospora and Monascus, microbial pigments, filamentous fungi, HMGCoA reductase, oncological diseases, hyperlipidaemia.

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VOLUME: 26
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Year: 2019
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