Background: Attention-deficit/hyperactivity disorder (ADHD) is a widespread diagnosis
that affects many children and adolescents’ ability to function and succeed in academics,
socially, or other situations. Non-stimulant medications have become widely utilized
in this population, especially in stimulant-resistant individuals, whether due to poor efficacy
or intolerance of side effects. However, these, too, harbor their own side effect profiles, including
cardiovascular and sleep or energy level disturbances.
Objectives: We review the literature in discussion of the presentation and management of
these adverse events for non-stimulant medications for ADHD, with a particular focus on
atomoxetine and alpha agonists guanfacine and clonidine.
Conclusion: Non-stimulants are for the most part well tolerated but monitoring for cardiac
and sleep difficulty is warranted.