Background: High-risk HPV subtypes are driving forces for human cancer development:
HPV-16 and HPV-18 are responsible for most HPV-caused cancers.
Objective: This review describes the present knowledge on HR-HPV genomes coding potential for viral
Methods: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics
and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and
validation by comparison with RNA sequencing datasets.
Results: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes.
Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene
targets that may be responsible for the oncogenesis in the various cellular environments.
Conclusion: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs,
directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells,
could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent