State-of-the-Art on Viral microRNAs in HPV Infection and Cancer Development

Author(s): Palmiro Poltronieri, Binlian Sun, Kai-Yao Huang, Tzu-Hao Chang, Tzong-Yi Lee*.

Journal Name: MicroRNA

Volume 7 , Issue 2 , 2018

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Abstract:

Background: High-risk HPV subtypes are driving forces for human cancer development: HPV-16 and HPV-18 are responsible for most HPV-caused cancers.

Objective: This review describes the present knowledge on HR-HPV genomes coding potential for viral miRNAs.

Methods: HPV subtypes miRNA database, VIRmiRtar, has been constructed applying bioinformatics and a computational method, ViralMir, exploiting structural features, the presence of hairpins, and validation by comparison with RNA sequencing datasets.

Results: Several miRNA candidates have been localised in the genomes of high-risk HPV subtypes. Among these, HPV-16 miR-1, miR-2 and miR-3. The database contains a list of host candidate gene targets that may be responsible for the oncogenesis in the various cellular environments.

Conclusion: miRNA silencing therapies, based on specific cellular uptake of miRNA mimics and antagomiRs, directed towards HPV encoded miRNAs and/or microRNAs deregulated in the host cells, could be a valuable approach to support pharmaceutical interventions in the treatment of HPV dependent cancers.

Keywords: Human Papilloma Virus (HPV), microRNAs, oncogenesis, seed sequence complementarity, translation repression, immunity.

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2018
Page: [85 - 91]
Pages: 7
DOI: 10.2174/2211536607666180328115155
Price: $58

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