Phage-based Nanomedicines as New Immune Therapeutic Agents for Breast Cancer

Author(s): Atefeh Arab, Rezvan Yazdian Robati, Jessica Nicastro, Roderick Slavcev, Javad Behravan*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 11 , 2018

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Abstract:

Despite years of investigation, breast cancer remains a major cause of death worldwide. Phage display is a powerful molecular method in which peptide and protein libraries can be displayed via genetic fusions on the surface of phages. This approach has tremendous potential for biomedical applications and has already facilitated the discovery of specific antibodies, specific antigens, and peptides with potential roles in the diagnosis and treatment of malignancies including breast cancer. In this review, we discuss the new and the latest advancements in the applications of the phage display technique in the provision of immune therapeutics for breast cancer.

Keywords: Bacteriophage, phage display, breast cancer, immune therapeutics, peptide library, vaccine.

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Article Details

VOLUME: 24
ISSUE: 11
Year: 2018
Page: [1195 - 1203]
Pages: 9
DOI: 10.2174/1381612824666180327152117
Price: $58

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