A new ring contraction of fused bis-lactams into spirolactams is presented here. In the presence
of a triflate catalyst in various solvents under microwave irradiation, this rearrangement allows a
clean conversion of some fused bicycles into spirocycles with good yields. The interest of this work
thus lies in the use of activated 2,5-diketopiperazines as starting materials and demonstrates the wide
range of applications of ring contraction reactions.
Keywords: Spirolactams, ring-contraction, heterocycles, homologous, cyclic compound, pyrrole.
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