Cytotoxic Pyran-based Cembranoids from Sarcophyton glaucum

Author(s): Walied M. Alarif*, Zahra A. Al-Saihati, Mohamed H. Ph, Ahmed Abdel-Lateff, Mahmoud A. Elfaky, Nahed O. Bawakid, Najla A. Alburae, Hajer S. Alorfi.

Journal Name: Letters in Organic Chemistry

Volume 15 , Issue 11 , 2018

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Abstract:

Four new pyran-based cembranoidal diterpenes (1-4) were isolated from the Red Sea softbodied coral Sarcophyton glaucum. Sarcoglauphine A (1) and B (2) are conformers with respect to the dihedral angle between H-7 and the pair of H-6a, 6b, while sarcotrocheliol-B acetate (3) and sarcotrochelione (4) are bicyclic cembranoids. The chemical structures of the isolated compounds were elucidated using spectroscopic methods. The cytotoxicity of the isolated compounds were evaluated against HepG2, MCF-7, and HCT116 cell lines by employing Sulforhodamine B (SRB) method. Compounds 1 and 2 showed significant activities toward HCT116.

Keywords: Soft coral, red sea, isomers, oxirane, diterpenoids, cemberane.

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Article Details

VOLUME: 15
ISSUE: 11
Year: 2018
Page: [967 - 971]
Pages: 5
DOI: 10.2174/1570178615666180326154819
Price: $58

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