Four new pyran-based cembranoidal diterpenes (1-4) were isolated from the Red Sea softbodied
coral Sarcophyton glaucum. Sarcoglauphine A (1) and B (2) are conformers with respect to the
dihedral angle between H-7 and the pair of H-6a, 6b, while sarcotrocheliol-B acetate (3) and
sarcotrochelione (4) are bicyclic cembranoids. The chemical structures of the isolated compounds were
elucidated using spectroscopic methods. The cytotoxicity of the isolated compounds were evaluated
against HepG2, MCF-7, and HCT116 cell lines by employing Sulforhodamine B (SRB) method. Compounds
1 and 2 showed significant activities toward HCT116.
Keywords: Soft coral, red sea, isomers, oxirane, diterpenoids, cemberane.
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