Synthesis, Nematicidal Activity and Docking Study of Novel Pyrazole-4-Carboxamide Derivatives Against Meloidogyne incognita

Author(s): Long Cheng, Wen Zhao, Zhong-Hua Shen, Tian-Ming Xu, Hong-Ke Wu, Wei-Li Peng*, Xing-Hai Liu*.

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 1 , 2019

Submit Manuscript
Submit Proposal

Graphical Abstract:


Abstract:

Background: A series of novel 2,6-dichloro-4-(trifluoromethyl)phenyl)-3-(difluoromethyl)- 1H-pyrazole-4-carboxamide derivatives were designed and synthesized.

Methods: All the title compounds were confirmed by 1H NMR and MS.

Results and Conclusion: The primarily nematicidal activity results indicated that some of them exhibited moderate control efficacy against the tomato root-knot nematode disease caused by Meloidogyne incognita.

Keywords: Difluoromethylpyrazole, alkyl chain, nematicidal activity, synthesis, docking, Meloidogyne incognita.

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 16
ISSUE: 1
Year: 2019
Page: [29 - 35]
Pages: 7
DOI: 10.2174/1570180815666180326150827
Price: $58

Article Metrics

PDF: 19
HTML: 1