Brain ischemia is among the leading cause of death with majority of the cases are associated
with ischemic strokes. It can occur in two forms of either focal or global ischemia. Neurodegenerative
disorder such as Alzheimer and Parkinson diseases is also on the rise worldwide. These disorders
have common similarities; i.e. they all affecting the central nervous system with debilitating effect
to the patient. In this review, we look into the promising role of flavonoids, a natural bioactive
compound found abundant in vegetables, fruits and traditional herbs. Treatment with flavonoids such
as curcumin, lycopene, ginsenoside, vitexin and baicalin have shown promising neuroprotective effects
against ischemic-induced injury. Besides anticancer, antioxidant and immunomodulation properties,
flavonoid also exerts neuroprotective effects by increases neuronal viability, increases tissue perfusion
and cerebral blood flow and reduce ischemic-related apoptosis. In addition, flavonoid also exerts
anti-amyloidogenic effect and reduces loss of dopaminergic neurons in the brain. These results
suggesting flavonoids might be able to serve as a potential therapeutic agent in brain disorders.
Keywords: Ischemia, Alzheimer disease, Parkinson disease, polyphenol, herb, natural products.
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