Several studies have investigated the risk factors associated with asthma.
Both genetic and environmental factors are considered to contribute to asthma
susceptibility. Individual genetic association studies usually suffer from small sample
size leading to biased results. Meta-analysis is a powerful tool that has the potential to
resolve this limitation by increasing the statistical power of analyses. The current review
summarizes the recent knowledge concerning genetic factors involved in asthma
predisposition based on meta-analyses. Using the keywords: asthma, meta-analysis,
polymorphism, we searched Pubmed, Medline, Embase and Google Scholar databases
for the associated articles. Genetic polymorphisms in twenty-three genes are associated
with asthma risk in meta-analyses. However, polymorphisms in nine genes showed
none significant association. These findings are used to assess the genetic risk factors
and to understand the molecular pathways related to asthma.
Keywords: Asthma, genetic polymorphism, single nucleotide polymorphism, cytokine, genetic association, metaanalysis.
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