In-Vitro Drug Dissolution Studies in Medicinal Compounds

Author(s): Burcin Bozal-Palabiyik, Bengi Uslu*, Yalcin Ozkan*, Sibel A. Ozkan.

Journal Name: Current Medicinal Chemistry

Volume 25 , Issue 33 , 2018

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Abstract:

After oral administration, drug absorption from solid dosage forms depends on the release of the drug active compounds from the dosage form, the dissolution or solubilization of the drug under physiological conditions, and the permeability across the gastrointestinal tract. Dissolution testing is an essential part of designing more effective solid dosage forms in pharmaceutical industry. Moreover, dissolution testing contributes to the selection of appropriate formulation excipients for improving the dosage form efficiency. This study aims to analyze in-vitro drug dissolution testing in solid dosage forms since 2010 in order to present a comprehensive outlook of recent trends. In doing that the previous studies in the literature are summarized in the form of a table to demonstrate the apparatuses used for dissolution testing, the media in which the solid dosage form is dissolved, the method preferred for analysis from dissolution media, the conditions of analyses and the results obtained.

Keywords: Dissolution testing, solid dosage forms, analysis, USP apparatuses, drug, validation.

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Article Details

VOLUME: 25
ISSUE: 33
Year: 2018
Page: [4020 - 4036]
Pages: 17
DOI: 10.2174/0929867325666180322145335
Price: $58

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