Current Applications of the Sonogashira Reaction in the Synthesis of Heterocyclic Compounds: An Update

Author(s): Majid M. Heravi*, Manizheh Ghanbarian, Nastaran Ghalavand, Niousha Nazari.

Journal Name: Current Organic Chemistry

Volume 22 , Issue 14 , 2018

Graphical Abstract:


Abstract:

The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.

Keywords: Sonogashira, palladium, Pd-catalyzed, Cu-catalyzed, Cu-free, 2-Formyl/acetyl-N-substituted pyrrolo[2, 3-b]quinoxaline, H-Pyrazolo[5, 1-a]isoquinolines, name reaction.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 22
ISSUE: 14
Year: 2018
Page: [1420 - 1457]
Pages: 38
DOI: 10.2174/1385272822666180322122232
Price: $58

Article Metrics

PDF: 23
HTML: 4