Lateral Flow Assay for Interleukin 6: A Technological and Scientific Prospection of a 10-Year Survey

Author(s): Ingridi de Souza Sene*, Vladimir Costa, Gisele Elias Nunes Pauli, Ivan H. Bechtold, Livio Cesar Cunha Nunes, Carla Eiras, Carlos Henrique Nery Costa.

Journal Name: Recent Patents on Biotechnology

Volume 12 , Issue 3 , 2018

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Graphical Abstract:


Background: Interleukin-6 (IL-6) is a multifunctional cytokine that plays a crucial role not only in the immune system but also in numerous biological processes. Elevated IL-6 levels have been observed in many types of cancer and inflammatory diseases. Among the techniques that have been used to quantify IL-6, a Lateral Flow Assay (LFA) is one of the most promising.

Objective: The objective of this study was to perform a technological and scientific exploration of the development of an LFA for IL-6.

Method: The Instituto Nacional de Propriedade Industrial-INPI (Brazil), European Patent Office – Espacenet, and United States Patent and Trademark Office-USPTO were used for the technological prospection to consider all the patents regarding an LFA for IL-6 detection. For the scientific investigation, the following periodic databases were used: Web of Science, Science Direct, PubMed, and Scielo, and were monitored from 2007 to May 2017.

Results: We found no patents based on the searched keywords, and a limited number of scientific articles were found. Therefore, the development of an LFA sensor for the detection of IL-6 appears to be innovative with significant biotechnological importance, creating a technology transfer to promote economic and industrial growth.

Conclusion: The development of lateral flow immunosensors for IL-6 is innovative, as we could not find patents describing such a biosensor. Scientific prospection reported two lateral flow immunosensors. However, the test for IL-6 cannot be completed without using some kind of equipment for detection, such as the one we propose in future developments.

Keywords: Biosensor, diagnostics, IL-6 detection, interleukin, lateral flow assay, prospective study.

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Article Details

Year: 2018
Page: [221 - 228]
Pages: 8
DOI: 10.2174/1872208312666180321113248
Price: $58

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