Background: Bile salts possess unique chemical structural characteristics and are
very different from conventional surfactants. Due to the fascinating physiological functions,
the bile salts have been widely studied by various physical methods. Last three decades are
the witness about rapid studies on bile salts aggregation with surfactant but yet uncertain
related to mixed micellar system.
Objective: The primary objective of this study was to undertake systematic studies on the
mixed systems comprising of cationic surfactant CPyCl + bile salts in water and NaCl
solution by surface tension and viscosity method.
Methods: Drop weight method (surface tension method) and viscometry methods are chosen
to discuss the interaction between bile salts and surfactant mixed system.
Results: Systematic studies on CPyCl + bile salts were carried out using Rubingh’s regular
solution theory in presence/absence of NaCl. The CMC and viscosity data measurements
were recorded. Molecular interaction parameters β was calculated to determine the depth of
synergism between the micellar systems.
Conclusions: Synergisms occur when cationic surfactant CPyCl and bile salts such as
NaDC/NaC were mixed. NaCl has the ability to modify the structure of CPyCl and bile salts.
Micelle size grows with increase in NaCl concentration. CMC of CPyCl decreases as the
concentration of salts increases. Viscosity data reveals that size of CPyCl micelle increases
with increasing NaCl concentration.