Aim and Objective: The present method is simple, green and highly efficient for the
synthesis of 2-amino-4H-pyran derivatives which are achieved by a one pot three component
cyclocondensation of aldehyde, malanonitrile and ethyl acetoacetate or methyl acetoacetate using
DABCO under solvent free with grinding conditions at room temperature.
Material and Methods: Some of the synthesized compounds were screened for their antimicrobial
and antifungal activity. The study shows that these compounds show good antimicrobial activity.
Furthermore, eight of the synthesized compounds were selected for screening of their anticancer
activity against human astrocytoma-glioblastoma cell line (U373MG). Some of the compounds show
good anticancer activity.
Result: Grinding synthesis of 2-amino-4H-pyran derivatives catalyzed by DABCO with various
aromatic aldehydes under solvent-free conditions at room temperature was examined. The obtained
compounds (22 entries) were well synthesized in good to excellent yields.
Conclusion: The present method is simple, rapid, and most efficient green protocol for the synthesis
of 2-amino-4H-pyran derivatives using highly inexpensive and easily available DABCO as an
efficient catalyst under grinding and solvent free condition at room temperature.