Evidence of Association between Epstein Barr Virus Serum Antibodies with HAs and RI as Biomarkers of Active Rheumatoid Arthritis

Author(s): German Perez, Maria Jose Svetaz, Leda Urli, Ricardo Volpintesta, Miguel Angel Taborda, Daniela Gardiol, Adriana Gir, Alejandra Luquita*.

Journal Name: Current Biomarkers (Under Re-organization)
Formerly: Recent Patents on Biomarkers

Volume 7 , Issue 1 , 2017

Graphical Abstract:


Abstract:

Background: Epstein Barr Virus (EBV) infection has been associated with the Rheumatoid Arthritis (RA) etiopathology, thus, considering it a relevant etiological agent in the disease development. We have previously observed the Hyaluronic Acid (HA) serum increase in active RA patients (DAS 28-4 > 2.6) which might be responsible for the erythrocyte deformability, estimated by the erythrocyte Rigidity Index (RI).

Objective: In the present study, we analyzed in one hundred RA patients if anti-EBV serum antibodies (TsEBV) and HA and RI levels are related with the disease activity.

Results: [HA] s [[controls]]: 20.0 ± 9; [HA] s [[AR]]: 155.8 ± 44 (p< 0.00001 vs. controls (n:40). Antibodies anti-EBV (1/ TsEBV) [[controls]]: 2.55 ± 0.49; [[RA]]: 1.85 ± 0.35 (p< 0.00001 vs. controls). There were significant correlations between DAS 28-4 vs. log2 1/TsEBV (r: 0.70, p < 0.00001) and DAS 28-4 vs. RI (r: 0.75, p < 0.00001) in active RA patients. However, we observed a strong positive correlation between [HA] s in active RA patients vs. log2 1/TsEBV (r: 0.83, p < 0.00001) and [HA] s vs. RI (r: 0.91, p < 0.00001).

Conclusion: The correlation obtained points out that the TsEBV may be related with the degree of RA activity determined by DAS28-4 and [HA]s in these patients. There was also a decrease in erythrocyte deformability estimated as RI, which is correlated with the DAS 28-4 activity index. Therefore, RI can be used as a reliable marker of RA activity. These findings might suggest a role of EBV infection regarding an autoimmune mechanism present in RA.

Keywords: Disease activity Score 28-4, Epstein - Barr virus, erythrocyte deformability, erythrocyte rigidity index, hyaluronic acid, rheumatoid arthritis.

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Article Details

VOLUME: 7
ISSUE: 1
Year: 2017
Page: [41 - 46]
Pages: 6
DOI: 10.2174/2468422808666180314120112
Price: $58

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