2-Pyrazolines as Biologically Active and Fluorescent Agents, An Overview

Author(s): Pramod Singh* , Jitendra Singh , Geeta J. Pant* , Mohan S.M. Rawat .

Journal Name: Anti-Cancer Agents in Medicinal Chemistry

Volume 18 , Issue 10 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Nitrogen-containing five-membered heterocyclics play a vital role in pharmaceuticals as well as medicinal chemistry. Pyrazolines play a significant role among other heterocycles because of their therapeutic and pharmacological properties. 2-Pyrazolines displayed a wide variety of biological activities such as anticancer, antiepileptic, anti-aids, antimalarial, insecticidal, antitubercular, etc. and they are used as pesticides, herbicides, fungicides and also used in agrochemical research and analytical chemistry. 2-Pyrazolines are well-known brightening agents used in chemosensor. They have excellent fluorescent properties and are widely used in synthetic fibers, dyes, photography and hole transporting materials. A number of preparation methods of pyrazolines have also been investigated by several research groups. In this review, most of the synthesized and reported nitrogen-containing five-membered heterocycles including 2-pyrazolines, their pharmaceutical evaluation and structure-reactivity are discussed.

Keywords: Biological activities, brightening agents, chalcones, fluorescence, heterocycles, 2-pyrazolines.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 18
ISSUE: 10
Year: 2018
Page: [1366 - 1385]
Pages: 20
DOI: 10.2174/1871520618666180313153407
Price: $58

Article Metrics

PDF: 32
HTML: 2
EPUB: 1
PRC: 1