Background: A series of new 6-(tert-butyl)-8-chloro-2,3-dimethyl quinoline derivatives
were designed and synthesized.
Results: The primarily antifungal assay results indicated that all of them exhibited excellent
protective efficacy (100%) against Pyricularia oryae at 100 ppm, except compound 2m (90%).
Among them, the compound 2p (6-(tert-butyl)-8-chloro-2,3-dimethylquinolin-4-yl(2-chloro-5-
(trifluoromethyl)benzyl)carbonate) possessed the highest fungicidal efficacy against Pyricularia
oryae, even at 10 ppm.
Conclusion: The structure-activity relationship showed that when the 2-position of benzene ring
was substituted by F or Cl, the compound possessed good antifungal activity against Pyricularia