Background: The widespread applications of sulphonamides, as antibacterial or antimicrobial
agents, and their mechanism of actions in the body, have changed their determination to an important
issue in the area of human health.
Objective: Here, history of developing voltammetric sensors based on nanomaterials for the detection of
sulfonamides including sulfadiazine, sulfamethoxazole, sulfacetamide, sulfadimethoxine, sulfathiazole,
sulfamethiazole and sulfamerazine is reviewed. Modified electrodes based on various nanomaterials
(carbonaceous nanomaterials, Metallic Nanoparticles (MNPs), conducting nanopolymers) have been
reported, and studies showed that nanomaterials have been mostly used to overcome problems like the
poor sensitivity and selectivity of bare electrodes. The study covers the properties of each sensor in
detail, and reports and compares the linear ranges, Limits of Detection (LODs), reproducibility, and
reusability of the electrodes reported so far.