Targeting the Microcirculation by Indole-3-carbinol and Its Main Derivate 3,3,’-diindolylmethane: Effects on Angiogenesis, Thrombosis and Inflammation

Author(s): Emmanuel Ampofo*, Beate M. Schmitt, Michael D. Menger, Matthias W. Laschke.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 11 , 2018

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

The pharmacological targeting of microcirculatory dysregulations is a therapeutic strategy for the treatment of numerous pathological conditions, such as cancer, thrombosis and inflammation. A promising candidate for this purpose is indole-3-carbinol (I3C), a phytochemical compound of cruciferous vegetables, and its main derivate 3,3,’-diindolylmethane (DIM). As summarized in this review, I3C and DIM affect multiple molecular and cellular processes within the microcirculation due to their pleiotropic action profile. These include angiogenesis, leukocyte-endothelial cell interaction, cytokine and reactive oxygen species (ROS) production, thrombus formation and microvascular leakage. Hence, I3C may serve as a lead compound for the future chemical synthesis of novel drugs that exert comparable beneficial effects while exhibiting an improved bioavailability.

Keywords: Angiogenesis, endothelial cells, indole-3-carbinol, inflammation, microcirculation, leukocytes, reactive oxygen species, thrombosis.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 18
ISSUE: 11
Year: 2018
Page: [962 - 968]
Pages: 7
DOI: 10.2174/1389557518666180313100144
Price: $58

Article Metrics

PDF: 37
HTML: 4
EPUB: 1
PRC: 1