Background: Diabetic foot ulcer is a common disorder involving diabetic patients.
Appling new indicators of the severity of diabetic foot infection may help the practitioners
to develop more efficient diagnosis and treatment strategies.
Methods: In this study, 70 diabetic patients with a foot ulcer, admitted to the infectious
diseases ward of Tabriz education and treatment center between 2015 and 2016, were enrolled.
The severity of infection was determined according to the Infectious Diseases Society
of America clinical practice guideline. Twenty of these patients were excluded and
further examinations were performed on 50 patients. On the first day of hospitalization
and before antibiotic therapy, Erythrocyte Sedimentation Rate (ESR), C-reactive protein
(CRP), Procalcitonin (PCT), White blood cells (WBCs), Fasting blood sugar (FBS) and
HbA1C were measured. The level of these factors was then compared across four severity
Results: Pulse rate, respiratory rate, body temperature and leukocyte count were significantly
higher in the patients with severe infection. ESR and CRP were higher in patients
with more severe infection, but PCT and HbA1C level were not in accordance with the
Conclusion: In conclusion, ESR and CRP level can be more successfully used to discriminate
patients, according to the severity of the infection.