Linking Antimicrobial Potential of Natural Products Derived from Aquatic Organisms and Microbes Involved in Alzheimer’s Disease - A Review

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Author(s): Dejan Stojkovic* , Marina Kostic , Marija Smiljkovic , Milena Aleksic , Perica Vasiljevic , Milos Nikolic , Marina Sokovic .

Journal Name: Current Medicinal Chemistry


The following review is oriented towards microbes linked to Alzheimer’s disease (AD) and antimicrobial effect of compounds and extracts derived from aquatic organisms against specific bacteria, fungi and viruses which were found previously in patients suffering from AD. Major group of microbes linked to AD include bacteria: Chlamydia pneumoniae, Helicobacter pylori, Porphyromonas gingivalis, Fusobacterium nucleatum, Prevotella intermedia, Actinomyces naeslundii, spirochete group; fungi: Candida sp., Cryptococcus sp., Saccharomyces sp., Malassezia sp., Botrytis sp., and viruses: herpes simplex virus type 1 (HSV-1), Human cytomegalovirus (CMV), hepatitis C virus (HCV). In the light of that fact, this review is the first to link antimicrobial potential of aquatic organisms against these sorts of microbes. This literature review might serve as a starting platform to develop novel supportive therapy for patients suffering from AD and to possibly prevent escalation of the disease in patients already having high-risk factors for AD occurrence.

Keywords: Alzheimer’s disease, bacteria, fungi, viruses, antimicrobial, aquatic organisms.

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(E-pub Ahead of Print)
DOI: 10.2174/0929867325666180309103645
Price: $95

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