Background: Diabetes mellitus is a major worldwide health concern that has several serious
complications including retinopathy, neuropathy, nephropathy and macrovascular diseases.
Objective: Dipeptidyl peptidase-IV (DPP-IV) inhibitors, gliptins, are a new class of antidiabetic agents
that potentiate the action of incretins in decreasing the blood glucose levels.
Methods: In the present study, synthesis and characterization of a series of ten N4-sulfonamido-acrylic
and phthalamic acid methyl esters (3a-e and 5a-e) were achieved.
Results: In vitro anti-DPP-IV activity of the synthesized compounds was evaluated, where compound
3b demonstrated the best activity with a % inhibition of 41.7 at 10 µM concentration and an IC50 of
23.9 µM. Moreover, Glide docking experiments revealed that our targeted compounds accommodate
the binding site of DPP-IV and tend to form H-bonding with the backbones of R125, E206, S209,
D545, K554, W629, Y631, and G632.
Conclusion: Modeling findings recommend the attachment of bulky hydrophobic group on the ester
side of the structure in addition to harboring extra aromatic rings that might be beneficial for better
binding interaction and biological activity.