Using Cholesterol as Low Molecular Mass Gelator for a New Nanogel Preparation

Author(s): A.P. Chiriac*, L.E. Nita, A. Diaconu, A.G. Rusu, I. Neamtu, D. Rusu.

Journal Name: Current Applied Polymer Science

Volume 2 , Issue 1 , 2018

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Graphical Abstract:


Background: The interest for nanogel systems is entirely justified as they are considered as the most effective carriers owing to their nanometer-sized dimensions, which allow holding more large amounts of solvent for incorporate bioactive drugs within their nanoscale three-dimensional polymer networks.

Objective: The research is following the synthesis and properties of a new nanogel structure based on poly(itaconic anhydride-co-3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5] undecane) and a low molecular mass gelator, namely cholesterol.

Method and Results: The chemical structure of the new network system was investigated by FTIR and 1HNMR. The sensitivity of the new structures was evaluated by determining the hydrodynamic radius in interdependence with the environmental condition.

Conclusion: The chemical composition of the new 3D structure was confirmed by FT-IR and 1HNMR spectroscopy. Also, the new PITAU_Ch presents a sinusoidal sensitivity with temperature, which was attributed to a new hydrophilic/hydrophobic status for the new compound.

Keywords: Cholesterol, itaconic anhydride, nanogel, polymer network, sensitive structure, spiroacetal moiety.

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Article Details

Year: 2018
Page: [37 - 43]
Pages: 7
DOI: 10.2174/2452271602666180308151225
Price: $58

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