VCP/p97/Cdc48, A Linking of Protein Homeostasis and Cancer Therapy

Author(s): B. Lan , S. Chai , P. Wang* , K. Wang* .

Journal Name: Current Molecular Medicine

Volume 17 , Issue 9 , 2017

  Journal Home
Translate in Chinese
Become EABM
Become Reviewer

Abstract:

VCP/p97/Cdc48, a member of the ATPases associated with diverse cellular activities (AAA) family, is necessary for the endoplasmic-reticulum-associated protein degradation (ERAD) pathway to maintain protein homeostasis. Overwhelming proteotoxic stress drove cancer cells to enhance VCP/p97/Cdc48-associated ERAD to maintain protein homeostasis for survival, demonstrating that VCP/p97/Cdc48 expression was positively correlated with cancer prognosis. More studies revealed that targeting VCP/p97/Cdc48 could be a potential target in cancer therapy. CB-5083, a novel inhibitor of VCP/p97/Cdc48, is in clinical trials as the first VCP/p97/Cdc48- inhibiting drug for cancer therapy. Here, we discuss the relationship between VCP/p97/Cdc48, ERAD, protein homeostasis and cancer therapy.

Keywords: VCP/p97/Cdc48, protein homeostasis, ERAD, cancer therapy, ER stress, CB-5083.

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 17
ISSUE: 9
Year: 2017
Page: [608 - 618]
Pages: 11
DOI: 10.2174/1566524018666180308111238
Price: $58

Article Metrics

PDF: 42
HTML: 10
EPUB: 1