Abstract
Introduction: A series of seventeen 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives (5a-8d) were synthesized and characterized by physical and spectral data (IR, 1H NMR, and mass spectroscopy) and evaluated for their antibacterial and antifungal activities against various pathogenic and non-pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial and antifungal activities.
Results and Discussions: Many of the tested compounds were found to be significantly active against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacterial strains (Escherichia coli, Salmonella typhi, Klebsiella pneumoniae and Pseudomonas aeruginosa), among which compounds 5a, 5b, 6a, 6b, 7a, 7b, 8a and 8b showed the maximum anti-bacterial activity but less effective than the standard ciprofloxacin. Almost all compounds from 5a-8d showed moderate activity against fungal strains like Candida albicans and Aspergillus niger.
Keywords: Imidazole derivatives, synthesis, antibacterial, antifungal activities, Anti-Microbial, Staphylococcus aureus.
Anti-Infective Agents
Title:Synthesis, Anti-Microbial Evaluation and Structure Activity Relationship (SAR) Studies of Some 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea Derivatives
Volume: 16 Issue: 1
Author(s): Rohit Singh*Swastika Ganguly
Affiliation:
- Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, Jharkhand,India
Keywords: Imidazole derivatives, synthesis, antibacterial, antifungal activities, Anti-Microbial, Staphylococcus aureus.
Abstract: Introduction: A series of seventeen 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea derivatives (5a-8d) were synthesized and characterized by physical and spectral data (IR, 1H NMR, and mass spectroscopy) and evaluated for their antibacterial and antifungal activities against various pathogenic and non-pathogenic microorganisms. Some of the synthesized compounds showed promising antibacterial and antifungal activities.
Results and Discussions: Many of the tested compounds were found to be significantly active against gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and gram-negative bacterial strains (Escherichia coli, Salmonella typhi, Klebsiella pneumoniae and Pseudomonas aeruginosa), among which compounds 5a, 5b, 6a, 6b, 7a, 7b, 8a and 8b showed the maximum anti-bacterial activity but less effective than the standard ciprofloxacin. Almost all compounds from 5a-8d showed moderate activity against fungal strains like Candida albicans and Aspergillus niger.
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Cite this article as:
Singh Rohit *, Ganguly Swastika , Synthesis, Anti-Microbial Evaluation and Structure Activity Relationship (SAR) Studies of Some 1-phenyl-3-(5-phenyl-1H-imidazol-1-yl) thiourea Derivatives, Anti-Infective Agents 2018; 16 (1) . https://dx.doi.org/10.2174/2211352516666180307155830
DOI https://dx.doi.org/10.2174/2211352516666180307155830 |
Print ISSN 2211-3525 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-3533 |
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