Objectives: to compare the prevalence of target-organ damage (TOD), defined as carotid
plaque, or intima media thickness, cIMT, >0.9 mm, and that of increased renal resistive index
(RRI), among HIV-1-infected patients and uninfected hypertensive patients (HT-non HIV).
Methods: HIV-infected patients aged ≥ 18 years and virologically suppressed were matched with
pair-age, sex and BMI HT-non HIV. Patients on antihypertensive treatment were excluded. All
patients’ cIMT and RRI were evaluated with ultrasonography.
Data were analysed throughout Χ2 test, analysis of variance and logistic regression.
Results: Fifty-nine HIV-infected patients were enrolled (71% men) and matched with 59 HT-non
HIV. No differences were found in cIMT values (p=0.827) and in the prevalence of TOD between
HIV-infected patients and HT-non HIV (36% vs 38%, p= 0.79).
Among HIV-infected patients, those hypertensive had significantly higher prevalence of TOD (46%
vs 21%, P< 0.05) and higher cIMT (0.747 ± 0.104 vs 0.654 ±0.100 mm, p = 0.0185).
Patients with TOD were older (p= 0.004) and more frequently current smokers (p= 0.022).
At the logistic regression analysis, TOD was significantly related to age (p=0.04, 95%CI 1.0-1.1)
and smoke, current (p=0.178, 95%CI1.2-12.8) or previous (p=0.04, 95%CI 1.0-7.2).
Mean RRI were identical for both HIV-1 infected and uninfected patients (0.60, SD± 0.05 and 0.60,
SD± 0.04, respectively, p=0.996).
Conclusions: In our study TOD was associated to hypertension, older age and smoke, but not to
HIV serostatus itself, confirming the major importance of traditional risk factors and the need of
risk assessment and cardiovascular prevention measures in HIV-infected patients.